In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study
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منابع مشابه
In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study.
Dietary intake of isothiocyanates (ITC) has been associated with reduced cancer risk. The dietary phenethyl ITC (PEITC) has previously been shown to decrease the phosphorylation of the translation regulator 4E binding protein 1 (4E-BP1). Decreased 4E-BP1 phosphorylation has been linked to the inhibition of cancer cell survival and decreased activity of the transcription factor hypoxia-inducible...
متن کاملCell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)
A fundamental control point in the regulation of the initiation of protein synthesis is the formation of the eukaryotic initiation factor 4F (eIF-4F) complex. The formation of this complex depends upon the availability of the mRNA cap binding protein, eIF-4E, which is sequestered away from the translational machinery by the tight association of eIF-4E binding proteins (4E-BPs). Phosphorylation ...
متن کاملRegulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
The multisubunit eukaryotic translation initiation factor (eIF) 4F recruits 40S ribosomal subunits to the 5' end of mRNA. The eIF4F subunit eIF4E interacts directly with the mRNA 5' cap structure. Assembly of the eIF4F complex is inhibited by a family of repressor polypeptides, the eIF4E-binding proteins (4E-BPs). Binding of the 4E-BPs to eIF4E is regulated by phosphorylation: Hypophosphorylate...
متن کاملO-13: Phosphorylation of 4E-BP1 Promotes Translation at The Oocyte Spindle
Background: Fully grown mammalian oocyte utilizes transcripts synthetized and stored during earlier development. In the mouse oocyte there are three forms of cap-dependent translational repressors: 4E-BP1, 4E-BP2, and 4E-BP3. The dominant form, 4E-BP1, inhibits cap-dependent translation by binding to the eIF4E translation initiation factor. Hyperphosphorylation of 4E-BP1 disrupts this inhibitor...
متن کاملNew Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress*
Eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) is a translational repressor that is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. This study reports a physiological study of 4E-BP1 regulation by phosphorylation ...
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ژورنال
عنوان ژورنال: British Journal of Nutrition
سال: 2010
ISSN: 0007-1145,1475-2662
DOI: 10.1017/s0007114510002217